COVID-19 pandemic: protective role of vitamin D
https://doi.org/10.17749/2070-4909/farmakoekonomika.2020.044
Abstract
Introduction. The COVID-19 pandemic revealed the vulnerability of the general population to this infectious disease, which is determined by the lack of immunity to the new SARS-CoV-2 coronavirus and is characterized by cytokine storm in severe cases. One of the most important reasons for this vulnerability is a high occurrence rate of micronutrient deficiencies, and above all, vitamin D deficiency.
Aim. To systematize the available data on the role of vitamin D in the prevention of COVID-19 infection.
Materials and methods. Systematic computer analysis of the entire array of available scientific publications on coronaviruses (21,300 publications in PUBMED and preprint repositories, including 7,500 publications on COVID-19 and SARS-CoV-2) was performed. The methods of topological and metric data analysis were used. About 50 most informative sections were identified that were mainly associated with COVID-19 / SARS-CoV-2. The analysis of the obtained “map” of molecular pathophysiology of COVID-19 was performed.
Results. Vitamin D activates the expression of many genes involved in supporting the immunity against coronaviruses and other singlestranded RNA viruses (interferon-dependent protection). The results of the systematic analysis of the publications on coronavirus showed that vitamin D is important for attenuating the effects of the cytokine storm and compensating for chronic comorbid pathologies.
Conclusion. The compensation for vitamin D deficiency is an essential component of COVID-19 prevention. This tactics of prevention is less costly than managing patients with severe forms of COVID-19 and can help save public healthcare resources.
Supporting agencies: The study was funded by the RFBR grants 19-07-00356, 18-07-00944.
About the Authors
O. A. Gromova
V.A. Nasonov Research Institute of Rheumatology;
Federal Research Center “Informatics and Management of the Russian Academy of Sciences“
Russian Federation
Russian Federation
MD, Dr Sci Med, Professor, Senior Researcher, Scientific Director; Leading Researcher, Center for Big Data Analysis, Moscow State University
Author ID: 94901; Scopus Author ID: 7003589812;
WoS ResearcherID: J-4946-2017. RSCI SPIN-code: 6317-9833
34A Kashirskoye Shosse, Moscow 115522, Russia
44-2 Vavilova Str., Moscow 119333, Russia
I. Yu. Torshin
V.A. Nasonov Research Institute of Rheumatology;
Federal Research Center “Informatics and Management of the Russian Academy of Sciences“
Russian Federation
Russian Federation
MD, PhD, Senior Researcher, Federal Research Center “Informatics and Management”; Big Data Storage and Analysis Center,
Scopus Author ID: 7003300274; Author ID: 54104;
WoS ResearcherID: C-7683-2018. RSCI SPIN-code: 1375-1114
34A Kashirskoye Shosse, Moscow 115522, Russia
44-2 Vavilova Str., Moscow 119333, Russia
G. Kh. Gabdulina
Kazakh National Medical University named after S. D. Asfendiyarova
Kazakhstan
MD, PhD, Professor, Department of General Medical Practice No. 1
92 Tole Bi Str., Almaty 50012, Kazakhstan
Kazakhstan
MD, PhD, Professor, Department of General Medical Practice No. 1
92 Tole Bi Str., Almaty 50012, Kazakhstan
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Gromova O.A., Torshin I.Yu., Gabdulina G.Kh. COVID-19 pandemic: protective role of vitamin D. FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2020;13(2):132-145. (In Russ.) https://doi.org/10.17749/2070-4909/farmakoekonomika.2020.044
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